Function | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. |
Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 1Deubiquitinating Enzyme 1HubpUbiquitin Thioesterase 1Ubiquitin-Specific-Processing Protease 1 Cleaved Into - Ubiquitin Carboxyl-Terminal Hydrolase 1 - N-Terminal Fragment |
Database Links | Reactome: R-HSA-110314Reactome: R-HSA-6783310 |
Cellular Localisation | Nucleus |
Alternative Protein Names | Ubiquitin Carboxyl-Terminal Hydrolase 1 proteinDeubiquitinating Enzyme 1 proteinHubp proteinUbiquitin Thioesterase 1 proteinUbiquitin-Specific-Processing Protease 1 Cleaved Into - Ubiquitin Carboxyl-Terminal Hydrolase 1 - N-Terminal Fragment proteinUSP1 protein |
Information sourced from Uniprot.org