Function | Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). |
Protein Name | Uroporphyrinogen-Iii SynthaseUroiiisUrosHydroxymethylbilane Hydrolyase CyclizingUroporphyrinogen-Iii Cosynthase |
Database Links | Reactome: R-HSA-189451 |
Alternative Protein Names | Uroporphyrinogen-Iii Synthase proteinUroiiis proteinUros proteinHydroxymethylbilane Hydrolyase Cyclizing proteinUroporphyrinogen-Iii Cosynthase proteinUROS protein |
Information sourced from Uniprot.org