| Post Translational Modifications | May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects. May undergo ubiquitin-mediated proteasomal degradation. |
| Function | Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria. |
| Protein Name | Mitochondrial Brown Fat Uncoupling Protein 1Ucp 1Solute Carrier Family 25 Member 7Thermogenin |
| Database Links | Reactome: R-HSA-166187Reactome: R-HSA-167826Reactome: R-HSA-9844594 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Mitochondrial Brown Fat Uncoupling Protein 1 proteinUcp 1 proteinSolute Carrier Family 25 Member 7 proteinThermogenin proteinUCP1 proteinSLC25A7 proteinUCP protein |
Information sourced from Uniprot.org
