Human UCHL3 protein (Recombinant) (N-His) (STJP008930)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human UCHL3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | UCHL3 |
| Gene ID | 7347 |
| Uniprot ID | UCHL3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ala230 |
Additional Info
| Function | Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3Uch-L3Ubiquitin Thioesterase L3 |
| Database Links | Reactome: R-HSA-5689603Reactome: R-HSA-8866652Reactome: R-HSA-8951664 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 proteinUch-L3 proteinUbiquitin Thioesterase L3 proteinUCHL3 protein |
Information sourced from Uniprot.org