| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | 0.22 Mu m filtered solution of 50 mM HEPES pH 7.5, 200 mM NaCl, 10% Glycerol (v/v) , 1 mM TCEP. |
| Storage Instruction: | Store at-70 °C. This product is stable at ≤-70 °C for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
| Determination Method: | < 0.01 EU/Mu g of the protein by LAL method |
| Gene Symbol: | UBE2E1 |
| Gene ID: | 7324 |
| Uniprot ID: | UB2E1_HUMAN |
| Immunogen Region: | Ser2-Thr193 |
| Immunogen: | Recombinant Human Ubiquitin-conjugating enzyme E2 E1/UBE2E1 protein is produced by E. coli cells expression system. The target protein is expressed with sequence (Ser2-Thr193) of Human Ubiquitin-conjugating enzyme E2 E1/UBE2E1 (Accession # P51965) fu |
| Immunogen Sequence: | SDDDSRASTSSSSSSSSNQQ TEKETNTPKKKESKVSMSKN SKLLSTSAKRIQKELADITL DPPPNCSAGPKGDNIYEWRS TILGPPGSVYEGGVFFLDIT FTPEYPFKPPKVTFRTRIYH CNINSQGVICLDILKDNWSP ALTISKVLLSICSLLTDCNP ADPLVGSIATQYMTNRAEHD RMARQWTKRYAT |
| Post Translational Modifications | ISGylation suppresses ubiquitin E2 enzyme activity. Autoubiquitinated in vitro. |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Catalyzes monoubiquitination of other proteins in both an E3-dependent and E3-independent manner. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 E1(E3-Independent E2 Ubiquitin-Conjugating Enzyme E1E2 Ubiquitin-Conjugating Enzyme E1Ubch6Ubiquitin Carrier Protein E1Ubiquitin-Protein Ligase E1 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-141430Reactome: R-HSA-174048Reactome: R-HSA-174084Reactome: R-HSA-174154Reactome: R-HSA-174178Reactome: R-HSA-174184Reactome: R-HSA-176407Reactome: R-HSA-176408Reactome: R-HSA-176409Reactome: R-HSA-176412Reactome: R-HSA-179409Reactome: R-HSA-2467813Reactome: R-HSA-2559582Reactome: R-HSA-68867Reactome: R-HSA-69017Reactome: R-HSA-8853884Reactome: R-HSA-8866652Reactome: R-HSA-8866654Reactome: R-HSA-9687136Reactome: R-HSA-983168 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Ubiquitin-Conjugating Enzyme E2 E1 protein(E3-Independent E2 Ubiquitin-Conjugating Enzyme E1 proteinE2 Ubiquitin-Conjugating Enzyme E1 proteinUbch6 proteinUbiquitin Carrier Protein E1 proteinUbiquitin-Protein Ligase E1 proteinUBE2E1 proteinUBCH6 protein |
Information sourced from Uniprot.org
