Human UBE2T protein (Recombinant) (N-His) (STJP014722)

Name: Human UBE2T protein (Recombinant) (N-His) (STJP014722)
SKU: STJP014722-100
Price: 414.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP014722-100

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Short Description	Recombinant-Human UBE2T-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Applications	ELISA/WB
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Formulation	Supplied as a 0.22 Mu m filtered solution in 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	< 1 EU/µg as determined by LAL test.

Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.
Protein Name	Ubiquitin-Conjugating Enzyme E2 T Cell Proliferation-Inducing Gene 50 Protein E2 Ubiquitin-Conjugating Enzyme T Ubiquitin Carrier Protein T Ubiquitin-Protein Ligase T
Database Links	Reactome: R-HSA-6783310 Reactome: R-HSA-8866652
Cellular Localisation	Nucleus Accumulates To Chromatin
Alternative Protein Names	Ubiquitin-Conjugating Enzyme E2 T protein Cell Proliferation-Inducing Gene 50 Protein protein E2 Ubiquitin-Conjugating Enzyme T protein Ubiquitin Carrier Protein T protein Ubiquitin-Protein Ligase T protein UBE2T protein HSPC150 protein PIG50 protein

Information sourced from Uniprot.org