| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 TCell Proliferation-Inducing Gene 50 ProteinE2 Ubiquitin-Conjugating Enzyme TUbiquitin Carrier Protein TUbiquitin-Protein Ligase T |
| Database Links | Reactome: R-HSA-6783310Reactome: R-HSA-8866652 |
| Cellular Localisation | NucleusAccumulates To Chromatin |
| Alternative Protein Names | Ubiquitin-Conjugating Enzyme E2 T proteinCell Proliferation-Inducing Gene 50 Protein proteinE2 Ubiquitin-Conjugating Enzyme T proteinUbiquitin Carrier Protein T proteinUbiquitin-Protein Ligase T proteinUBE2T proteinHSPC150 proteinPIG50 protein |
Information sourced from Uniprot.org
