| Host: | E.coli |
| Applications: | SDS-PAGE |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human UbcH5b/UBE2D2-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications. |
| Formulation: | Liquid in 20mM MES buffer (pH 6.0) containing 50mM NaCl, 1mM DTT |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UBE2D2 |
| Gene ID: | 7322 |
| Uniprot ID: | UB2D2_HUMAN |
| Immunogen Region: | 1-147aa |
| Accession Number: | NP_003330 |
| Immunogen: | Human |
| Immunogen Sequence: | MALKRIHKEL NDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF FLTIHFPTDY PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV PEIARIYKTD REKYNRIARE WTQKYAM |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and SQSTM1 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 D2(E3-Independent E2 Ubiquitin-Conjugating Enzyme D2E2 Ubiquitin-Conjugating Enzyme D2Ubiquitin Carrier Protein D2Ubiquitin-Conjugating Enzyme E2(17kb 2Ubiquitin-Conjugating Enzyme E2-17 Kda 2Ubiquitin-Protein Ligase D2P53-Regulated Ubiquitin-Conjugating Enzyme 1 |
| Database Links | Reactome: R-HSA-1234176Reactome: R-HSA-168927Reactome: R-HSA-202424Reactome: R-HSA-2871837Reactome: R-HSA-5205685Reactome: R-HSA-5357905Reactome: R-HSA-5607764Reactome: R-HSA-8866652Reactome: R-HSA-8866654Reactome: R-HSA-8951664Reactome: R-HSA-9033241Reactome: R-HSA-936440Reactome: R-HSA-937041Reactome: R-HSA-9705462Reactome: R-HSA-983168 |
| Cellular Localisation | |
| Alternative Protein Names | Ubiquitin-Conjugating Enzyme E2 D2 protein(E3-Independent E2 Ubiquitin-Conjugating Enzyme D2 proteinE2 Ubiquitin-Conjugating Enzyme D2 proteinUbiquitin Carrier Protein D2 proteinUbiquitin-Conjugating Enzyme E2(17kb 2 proteinUbiquitin-Conjugating Enzyme E2-17 Kda 2 proteinUbiquitin-Protein Ligase D2 proteinP53-Regulated Ubiquitin-Conjugating Enzyme 1 proteinUBE2D2 proteinPUBC1 proteinUBC4 proteinUBC5B proteinUBCH4 proteinUBCH5B protein |
Information sourced from Uniprot.org
