| Host: | E.coli |
| Applications: | SDS-PAGE |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human UbcH5a/UBE2D1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 40% Glycerol, 0.1M NaCl |
| Concentration: | 1 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UBE2D1 |
| Gene ID: | 7321 |
| Uniprot ID: | UB2D1_HUMAN |
| Immunogen Region: | 1-147aa |
| Accession Number: | NP_003329 |
| Immunogen: | Human |
| Immunogen Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMALKRIQ KELSDLQRDP PAHCSAGPVG DDLFHWQATI MGPPDSAYQG GVFFLTVHFP TDYPFKPPKI AFTTKIYHPN INSNGSICLD ILRSQWSPAL TVSKVLLSIC SLLCDPNPDD PLVPDIAQIY KSDKEKYNRH AREWTQKYAM |
| Tissue Specificity | Ubiquitous. Up-regulated in livers of iron-overloaded patients with hereditary hemochromatosis. |
| Post Translational Modifications | Autoubiquitinated in vitro. |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 D1(E3-Independent E2 Ubiquitin-Conjugating Enzyme D1E2 Ubiquitin-Conjugating Enzyme D1Stimulator Of Fe TransportSftUbc4/5 HomologUbch5Ubiquitin Carrier Protein D1Ubiquitin-Conjugating Enzyme E2(17kb 1Ubiquitin-Conjugating Enzyme E2-17 Kda 1Ubiquitin-Protein Ligase D1 |
| Database Links | Reactome: R-HSA-1234176Reactome: R-HSA-141430Reactome: R-HSA-168927Reactome: R-HSA-174048Reactome: R-HSA-174084Reactome: R-HSA-174154Reactome: R-HSA-174178Reactome: R-HSA-174184Reactome: R-HSA-176407Reactome: R-HSA-176408Reactome: R-HSA-176409Reactome: R-HSA-176412Reactome: R-HSA-179409Reactome: R-HSA-201451Reactome: R-HSA-202424Reactome: R-HSA-2173795Reactome: R-HSA-2467813Reactome: R-HSA-2559582Reactome: R-HSA-2871837Reactome: R-HSA-5357905Reactome: R-HSA-5607764Reactome: R-HSA-5689896Reactome: R-HSA-68867Reactome: R-HSA-69017Reactome: R-HSA-8853884Reactome: R-HSA-8866652Reactome: R-HSA-8866654Reactome: R-HSA-8951664Reactome: R-HSA-9033241Reactome: R-HSA-936440Reactome: R-HSA-937041Reactome: R-HSA-9687136Reactome: R-HSA-9705462Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Ubiquitin-Conjugating Enzyme E2 D1 protein(E3-Independent E2 Ubiquitin-Conjugating Enzyme D1 proteinE2 Ubiquitin-Conjugating Enzyme D1 proteinStimulator Of Fe Transport proteinSft proteinUbc4/5 Homolog proteinUbch5 proteinUbiquitin Carrier Protein D1 proteinUbiquitin-Conjugating Enzyme E2(17kb 1 proteinUbiquitin-Conjugating Enzyme E2-17 Kda 1 proteinUbiquitin-Protein Ligase D1 proteinUBE2D1 proteinSFT proteinUBC5A proteinUBCH5 proteinUBCH5A protein |
Information sourced from Uniprot.org