Human UBA7 protein (Recombinant) (N-His) (STJP004698)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human UBA7-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | UBA7 |
| Gene ID | 7318 |
| Uniprot ID | UBA7_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys429-Val488 |
Additional Info
| Post Translational Modifications | ISGylated. Ubiquitinated by RNF170. |
| Function | E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation. Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus. For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition. ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling. |
| Protein Name | Ubiquitin-Like Modifier-Activating Enzyme 7Ubiquitin-Activating Enzyme 7D8Ubiquitin-Activating Enzyme E1 Homolog |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-168928Reactome: R-HSA-5656169Reactome: R-HSA-936440Reactome: R-HSA-983168Reactome: R-HSA-9909505 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Ubiquitin-Like Modifier-Activating Enzyme 7 proteinUbiquitin-Activating Enzyme 7 proteinD8 proteinUbiquitin-Activating Enzyme E1 Homolog proteinUBA7 proteinUBE1L proteinUBE2 protein |
Information sourced from Uniprot.org