Human UBA7 protein (Recombinant) (N-His) (STJP004698)

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STJP004698
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human UBA7-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: UBA7
Gene ID: 7318
Uniprot ID: UBA7_HUMAN
Immunogen Region: Lys429-Val488
Immunogen: Homo sapiens (Human)
Post Translational Modifications ISGylated. Ubiquitinated by RNF170.
Function E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation. Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus. For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition. ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling.
Protein Name Ubiquitin-Like Modifier-Activating Enzyme 7
Ubiquitin-Activating Enzyme 7
D8
Ubiquitin-Activating Enzyme E1 Homolog
Database Links Reactome: R-HSA-1169408
Reactome: R-HSA-168928
Reactome: R-HSA-5656169
Reactome: R-HSA-936440
Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Nucleus
Alternative Protein Names Ubiquitin-Like Modifier-Activating Enzyme 7 protein
Ubiquitin-Activating Enzyme 7 protein
D8 protein
Ubiquitin-Activating Enzyme E1 Homolog protein
UBA7 protein
UBE1L protein
UBE2 protein

Information sourced from Uniprot.org