Human U2AF2 protein (Recombinant) (N-His) (STJP009609)

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STJP009609
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human U2AF2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: U2AF2
Gene ID: 11338
Uniprot ID: U2AF2_HUMAN
Immunogen Region: Pro138-Gly338
Immunogen: Homo sapiens (Human)
Function Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals.
Protein Name Splicing Factor U2af 65 Kda Subunit
U2 Auxiliary Factor 65 Kda Subunit
Hu2af(65
Hu2af65
U2 Snrnp Auxiliary Factor Large Subunit
Database Links Reactome: R-HSA-159236
Reactome: R-HSA-72163
Reactome: R-HSA-72187
Reactome: R-HSA-73856
Reactome: R-HSA-9629569
Cellular Localisation Nucleus
Alternative Protein Names Splicing Factor U2af 65 Kda Subunit protein
U2 Auxiliary Factor 65 Kda Subunit protein
Hu2af(65 protein
Hu2af65 protein
U2 Snrnp Auxiliary Factor Large Subunit protein
U2AF2 protein
U2AF65 protein

Information sourced from Uniprot.org

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