| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
TWSG1 |
| Gene ID: |
57045 |
| Uniprot ID: |
TWSG1_HUMAN |
| Immunogen Region: |
Met1-Phe223 |
| Immunogen: |
Recombinant Human TWSG1 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Met1-Phe223) of human TWSG1 (Accession #NP_065699.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
MKLHYVAVLTLAILMFLTWL PESLSCNKALCASDVSKCLI QELCQCRPGEGNCSCCKECM LCLGALWDECCDCVGMCNPR NYSDTPPTSKSTVEELHEPI PSLFRALTEGDTQLNWNIVS FPVAEELSHHENLVSFLETV NQPHHQNVSVPSNNVHAPYS SDKEHMCTVVYFDDCMSIHQ CKISCESMGASKYRWFHNAC CECIGPECIDYGSKTVKCMN CMF |
| Function | May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development. |
| Protein Name | Twisted Gastrulation Protein Homolog 1 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Twisted Gastrulation Protein Homolog 1 proteinTWSG1 proteinTSG proteinPSEC0250 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
