Human TWIST1 protein (Recombinant) (N-His) (STJP005466)

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STJP005466
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TWIST1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TWIST1
Gene ID: 7291
Uniprot ID: TWST1_HUMAN
Immunogen Region: Met1-His202
Immunogen: Homo sapiens (Human)
Function Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer.
Protein Name Twist-Related Protein 1
Class A Basic Helix-Loop-Helix Protein 38
Bhlha38
H-Twist
Database Links Reactome: R-HSA-6785807
Reactome: R-HSA-8878166
Reactome: R-HSA-8939902
Reactome: R-HSA-9725371
Cellular Localisation Nucleus
Alternative Protein Names Twist-Related Protein 1 protein
Class A Basic Helix-Loop-Helix Protein 38 protein
Bhlha38 protein
H-Twist protein
TWIST1 protein
BHLHA38 protein
TWIST protein

Information sourced from Uniprot.org

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