| Function | Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes. |
| Protein Name | Tubby-Related Protein 3Tubby-Like Protein 3 |
| Database Links | Reactome: R-HSA-5610787 |
| Cellular Localisation | NucleusCell MembraneCell ProjectionCiliumCytoplasmSecretedDoes Not Have A Cleavable Signal Peptide And Is Secreted By A Non-Conventional PathwayTranslocates From The Plasma Membrane To The Nucleus Upon Activation Of Guanine Nucleotide-Binding Protein G(Q) Subunit Alpha |
| Alternative Protein Names | Tubby-Related Protein 3 proteinTubby-Like Protein 3 proteinTULP3 proteinTUBL3 protein |
Information sourced from Uniprot.org
