Tissue Specificity | Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. |
Post Translational Modifications | Phosphorylated by FYN, leading to an increase of TRPC6 channel activity. |
Function | Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. |
Protein Name | Short Transient Receptor Potential Channel 6Trpc6Transient Receptor Protein 6Trp-6 |
Database Links | Reactome: R-HSA-114508Reactome: R-HSA-139853Reactome: R-HSA-3295583Reactome: R-HSA-418890 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
Alternative ELISA Names | Short Transient Receptor Potential Channel 6 ELISA kitTrpc6 ELISA kitTransient Receptor Protein 6 ELISA kitTrp-6 ELISA kitTRPC6 ELISA kitTRP6 ELISA kit |
output | |
Information sourced from Uniprot.org