| Function | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway. The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1. |
| Protein Name | Short Transient Receptor Potential Channel 4-Associated ProteinTrp4-Associated ProteinTrpc4-Associated ProteinProtein Tap1Tnf-Receptor Ubiquitous Scaffolding/Signaling ProteinProtein Truss |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Protein Names | Short Transient Receptor Potential Channel 4-Associated Protein proteinTrp4-Associated Protein proteinTrpc4-Associated Protein proteinProtein Tap1 proteinTnf-Receptor Ubiquitous Scaffolding/Signaling Protein proteinProtein Truss proteinTRPC4AP proteinC20orf188 proteinTRRP4AP protein |
Information sourced from Uniprot.org
