| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human NTF3 at 2 Mu g/mL (100 Mu L/well) can bind Recombinant human TrkC with a linear range of 231-925 ng/mL. |
| Gene Symbol: | NTRK3 |
| Gene ID: | 4916 |
| Uniprot ID: | NTRK3_HUMAN |
| Immunogen: | Recombinant Human Trk-C/NTRK3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys32-Asp428) of human TrkC/NTRK3 (Accession #NP_001012338.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | CPANCVCSKTEINCRRPDDG NLFPLLEGQDSGNSNGNASI NITDISRNITSIHIENWRSL HTLNAVDMELYTGLQKLTIK NSGLRSIQPRAFAKNPHLRY INLSSNRLTTLSWQLFQTLS LRELQLEQNFFNCSCDIRWM QLWQEQGEAKLNSQNLYCIN ADGSQLPLFRMNISQCDLPE ISVSHVNLTVREGDNAVITC NGSGSPLPDVDWIVTGLQSI NTHQTNLNWTNVHAINLTL |
| Tissue Specificity | Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain. |
| Post Translational Modifications | Ligand-mediated auto-phosphorylation. |
| Function | Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. |
| Protein Name | Nt-3 Growth Factor ReceptorGp145-TrkcTrk-CNeurotrophic Tyrosine Kinase Receptor Type 3Trkc Tyrosine Kinase |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-388844Reactome: R-HSA-6811558Reactome: R-HSA-9034013Reactome: R-HSA-9034015Reactome: R-HSA-9034793Reactome: R-HSA-9034864Reactome: R-HSA-9603381Reactome: R-HSA-9603505 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Nt-3 Growth Factor Receptor proteinGp145-Trkc proteinTrk-C proteinNeurotrophic Tyrosine Kinase Receptor Type 3 proteinTrkc Tyrosine Kinase proteinNTRK3 proteinTRKC protein |
Information sourced from Uniprot.org
