| Tissue Specificity | Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors. |
| Post Translational Modifications | Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13. |
| Function | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. |
| Protein Name | Thyroid Receptor-Interacting Protein 6Tr-Interacting Protein 6Trip-6Opa-Interacting Protein 1Oip-1Zyxin-Related Protein 1Zrp-1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionFocal AdhesionNucleusShuttles Between Nucleus And CytoplasmColocalizes With Actin |
| Alternative ELISA Names | Thyroid Receptor-Interacting Protein 6 ELISA kitTr-Interacting Protein 6 ELISA kitTrip-6 ELISA kitOpa-Interacting Protein 1 ELISA kitOip-1 ELISA kitZyxin-Related Protein 1 ELISA kitZrp-1 ELISA kitTRIP6 ELISA kitOIP1 ELISA kit |
| output | |
Information sourced from Uniprot.org
