| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.135ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description : | This TRIP6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | TRIP6 |
| Gene ID: | 7205 |
| Uniprot ID: | TRIP6_HUMAN |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors. |
| Post Translational Modifications | Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13. |
| Function | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. |
| Protein Name | Thyroid Receptor-Interacting Protein 6 Tr-Interacting Protein 6 Trip-6 Opa-Interacting Protein 1 Oip-1 Zyxin-Related Protein 1 Zrp-1 |
| Database Links | |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Junction Focal Adhesion Nucleus Shuttles Between Nucleus And Cytoplasm Colocalizes With Actin |
| Alternative ELISA Names | Thyroid Receptor-Interacting Protein 6 ELISA kit Tr-Interacting Protein 6 ELISA kit Trip-6 ELISA kit Opa-Interacting Protein 1 ELISA kit Oip-1 ELISA kit Zyxin-Related Protein 1 ELISA kit Zrp-1 ELISA kit TRIP6 ELISA kit OIP1 ELISA kit |
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Information sourced from Uniprot.org