Human TRIM37 protein (Recombinant) (N-His) (STJP010773)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TRIM37-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TRIM37 |
| Gene ID | 4591 |
| Uniprot ID | TRI37_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser275-Ser405 |
Additional Info
| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes. Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome. Has anti-HIV activity. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim37Mulibrey Nanism ProteinRing-Type E3 Ubiquitin Transferase Trim37Tripartite Motif-Containing Protein 37 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | ChromosomeCytoplasmPerinuclear RegionPeroxisome MembranePeripheral Membrane ProteinFound In Vesicles Of The PeroxisomeAggregates As AggresomesA Perinuclear Region Where Certain Misfolded Or Aggregated Proteins Are Sequestered For Proteasomal Degradation |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Trim37 proteinMulibrey Nanism Protein proteinRing-Type E3 Ubiquitin Transferase Trim37 proteinTripartite Motif-Containing Protein 37 proteinTRIM37 proteinKIAA0898 proteinMUL proteinPOB1 protein |
Information sourced from Uniprot.org