Name: Human TRIM37 protein (Recombinant) (N-His) (STJP010773)
SKU: STJP010773
Availability: InStock

Human TRIM37 protein (Recombinant) (N-His) (STJP010773)

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STJP010773

$443.48 - $1,940.63

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Host:	E. coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Recombinant-Human TRIM37-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.

Formulation:	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Post Translational Modifications	Auto-ubiquitinated.
Function	E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes. Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome. Has anti-HIV activity.
Protein Name	E3 Ubiquitin-Protein Ligase Trim37 Mulibrey Nanism Protein Ring-Type E3 Ubiquitin Transferase Trim37 Tripartite Motif-Containing Protein 37
Database Links	Reactome: R-HSA-983168
Cellular Localisation	Chromosome Cytoplasm Perinuclear Region Peroxisome Membrane Peripheral Membrane Protein Found In Vesicles Of The Peroxisome Aggregates As Aggresomes A Perinuclear Region Where Certain Misfolded Or Aggregated Proteins Are Sequestered For Proteasomal Degradation
Alternative Protein Names	E3 Ubiquitin-Protein Ligase Trim37 protein Mulibrey Nanism Protein protein Ring-Type E3 Ubiquitin Transferase Trim37 protein Tripartite Motif-Containing Protein 37 protein TRIM37 protein KIAA0898 protein MUL protein POB1 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP005172	Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172)	E. coli
STJP004723	Human WAS protein (Recombinant) (N-His) (STJP004723)	E. coli
STJP003472	Human OTC protein (Recombinant) (N-His) (STJP003472)	E. coli
STJP003474	Human PNP protein (Recombinant) (N-His) (STJP003474)	E. coli
STJP003459	Human TOMM40 protein (Recombinant) (N-His) (STJP003459)	E. coli

Human TRIM37 protein (Recombinant) (N-His) (STJP010773)

General Information