Human TRIM33/TIF1-Gamma protein (Recombinant) (N-His) (STJP007315)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TRIM33/TIF1-Gamma-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TRIM33 |
| Gene ID | 51592 |
| Uniprot ID | TRI33_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp882-Ala1087 |
Additional Info
| Post Translational Modifications | Sumoylated with SUMO1. |
| Function | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim33Ectodermin HomologRet-Fused Gene 7 ProteinProtein Rfg7Ring-Type E3 Ubiquitin Transferase Trim33Transcription Intermediary Factor 1-GammaTif1-GammaTripartite Motif-Containing Protein 33 |
| Database Links | Reactome: R-HSA-2173795Reactome: R-HSA-9754189 |
| Cellular Localisation | NucleusIn Discrete Nuclear Dots Resembling Nuclear BodiesLocalizes To Sites Of Dna Damage |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Trim33 proteinEctodermin Homolog proteinRet-Fused Gene 7 Protein proteinProtein Rfg7 proteinRing-Type E3 Ubiquitin Transferase Trim33 proteinTranscription Intermediary Factor 1-Gamma proteinTif1-Gamma proteinTripartite Motif-Containing Protein 33 proteinTRIM33 proteinKIAA1113 proteinRFG7 proteinTIF1G protein |
Information sourced from Uniprot.org