Human TRIM33/TIF1-Gamma protein (Recombinant) (N-His) (STJP007315)

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STJP007315
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TRIM33/TIF1-Gamma-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TRIM33
Gene ID: 51592
Uniprot ID: TRI33_HUMAN
Immunogen Region: Asp882-Ala1087
Immunogen: Homo sapiens (Human)
Post Translational Modifications Sumoylated with SUMO1.
Function Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
Protein Name E3 Ubiquitin-Protein Ligase Trim33
Ectodermin Homolog
Ret-Fused Gene 7 Protein
Protein Rfg7
Ring-Type E3 Ubiquitin Transferase Trim33
Transcription Intermediary Factor 1-Gamma
Tif1-Gamma
Tripartite Motif-Containing Protein 33
Database Links Reactome: R-HSA-2173795
Reactome: R-HSA-9754189
Cellular Localisation Nucleus
In Discrete Nuclear Dots Resembling Nuclear Bodies
Localizes To Sites Of Dna Damage
Alternative Protein Names E3 Ubiquitin-Protein Ligase Trim33 protein
Ectodermin Homolog protein
Ret-Fused Gene 7 Protein protein
Protein Rfg7 protein
Ring-Type E3 Ubiquitin Transferase Trim33 protein
Transcription Intermediary Factor 1-Gamma protein
Tif1-Gamma protein
Tripartite Motif-Containing Protein 33 protein
TRIM33 protein
KIAA1113 protein
RFG7 protein
TIF1G protein

Information sourced from Uniprot.org

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