| Post Translational Modifications | Ubiquitinated. Undergoes 'Lys-63'-linked polyubiquitination.this modification allows IKBKG/NEMO recruitment to MAVS. Undergoes 'Lys-48'-linked polyubiquitination by RNF125.this modification mediates its degradation via the ubiquitin-proteasome pathway. |
| Function | Plays an essential role in the innate immune defense against viruses and bacteria. Promotes the 'Lys-48'-linked ubiquitination and subsequent degradation of hepatitis C virus NS5A leading to the inhibition of viral replication. Plays also a role in the inhibition of ebolavirus infection by enhancing IFN-beta and NF-kappa-B activation after binding to the viral protein NP. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation. Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression. Inhibits the transcriptional activity of SPI1 in a dose-dependent manner. Inhibits also OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3. Mechanistically, recruits USP14 to remove the 'Lys-63'-linked ubiquitination of KDM4D, preventing its recognition by OPTN and subsequent degradation. |
| Protein Name | Tripartite Motif-Containing Protein 14 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | Mitochondrion Outer MembraneCytoplasmic VesiclePhagosomeNucleus |
| Alternative Protein Names | Tripartite Motif-Containing Protein 14 proteinTRIM14 proteinKIAA0129 protein |
Information sourced from Uniprot.org
