SDS-PAGE gel of recombinant human TREM1 protein 3µg under reducing conditions stained with Coomassie blue

Human TREM1 protein (Recombinant) (His-Tag) (STJP017879)

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STJP017879
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Short Description :Recombinant-Human TREM1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% Glycerol, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:TREM1
Gene ID:54210
Uniprot ID:TREM1_HUMAN
Accession Number:NP_061113.1
Immunogen:Human
Immunogen Region:21-205aa
Immunogen Sequence:ATKLTE EKYELKEGQT LDVKCDYTLE KFASSQKAWQ IIRDGEMPKT LACTERPSKN SHPVQVGRII LEDYHDHGLL RVRMVNLQVE DSGLYQCVIY QPPKEPHMLF DRIRLVVTKG FSGTPGSNEN STQNVYKIPP TTTKALCPLY TSPRTVTQAP PKSTADVSTP DSEINLTNVT DIIRVPVFN
Tissue Specificity Mostly expressed by immune cells of the myeloid lineage, such as monocytes, macrophages, neutrophils and dendritic cells. Expression is associated with a mature stage of myeloid development. Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Isoform 2 was detected in the lung, liver and mature monocytes.
Post Translational Modifications Glycosylated.
Function Isoform 1: Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis. Isoform 2: Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its ligand.
Protein Name Triggering Receptor Expressed On Myeloid Cells 1
Trem-1
Triggering Receptor Expressed On Monocytes 1
Cd Antigen Cd354
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-202733
Reactome: R-HSA-2172127
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Recruited To Lipid Rafts When Activated
Isoform 2: Secreted
Alternative Protein Names Triggering Receptor Expressed On Myeloid Cells 1 protein
Trem-1 protein
Triggering Receptor Expressed On Monocytes 1 protein
Cd Antigen Cd354 protein
TREM1 protein

Information sourced from Uniprot.org

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