• Human TREM-1/CD354 protein (Recombinant) (C-hFc&His) (STJP000943)

Human TREM-1/CD354 protein (Recombinant) (C-hFc&His) (STJP000943)

SKU:
STJP000943

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human TREM-1/CD354-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Gene Symbol: TREM1
Gene ID: 54210
Uniprot ID: TREM1_HUMAN
Immunogen: Recombinant Human TREM1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala21-Arg200) of human TREM1 (Accession #NP_061113.1) fused with an Fc, 6×His tag at the C-terminus.
Tissue Specificity Mostly expressed by immune cells of the myeloid lineage, such as monocytes, macrophages, neutrophils and dendritic cells. Expression is associated with a mature stage of myeloid development. Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Isoform 2 was detected in the lung, liver and mature monocytes.
Post Translational Modifications Glycosylated.
Function Isoform 1: Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis. Isoform 2: Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its lignad.
Protein Name Triggering Receptor Expressed On Myeloid Cells 1
Trem-1
Triggering Receptor Expressed On Monocytes 1
Cd Antigen Cd354
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-202733
Reactome: R-HSA-2172127
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Recruited To Lipid Rafts When Activated
Isoform 2: Secreted
Alternative Protein Names Triggering Receptor Expressed On Myeloid Cells 1 protein
Trem-1 protein
Triggering Receptor Expressed On Monocytes 1 protein
Cd Antigen Cd354 protein
TREM1 protein

Information sourced from Uniprot.org

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