| Function | E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3. If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway. Only catalyzes ubiquitination of MCM7 when forks converge. Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome. Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity. The function in translesion synthesis is however controversial. Acts as a regulator of the spindle assembly checkpoint. Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation. |
| Protein Name | E3 Ubiquitin-Protein Ligase TraipRing Finger Protein 206Traf-Interacting Protein |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusNucleoplasmNucleolusChromosomeCytoplasmPerinuclear RegionIn The NucleusFound In Close Proximity To PcnaSuggesting Localization At Replication FociLocalizes To Dna Damage Sites In Response To Replication Stress |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Traip proteinRing Finger Protein 206 proteinTraf-Interacting Protein proteinTRAIP proteinRNF206 proteinTRIP protein |
Information sourced from Uniprot.org
