Post Translational Modifications | Ubiquitinated at Lys-318 by the SCF(FBXL2) complex, leading to its degradation by the proteasome. |
Function | Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. |
Protein Name | Tnf Receptor-Associated Factor 5Ring Finger Protein 84 |
Cellular Localisation | CytoplasmCytosol |
Alternative Protein Names | Tnf Receptor-Associated Factor 5 proteinRing Finger Protein 84 proteinTRAF5 proteinRNF84 protein |
Information sourced from Uniprot.org