Human TRAF3IP2 protein (Recombinant) (N-His) (STJP010688)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TRAF3IP2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TRAF3IP2 |
| Gene ID | 10758 |
| Uniprot ID | CIKS_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser403-Arg554 |
Additional Info
| Function | E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling. Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein. Essential adapter molecule in IL17A-mediated signaling. Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways. |
| Protein Name | E3 Ubiquitin Ligase Traf3ip2Adapter Protein CiksConnection To Ikk And Sapk/JnkE3 Ubiquitin-Protein Ligase CiksNuclear Factor Nf-Kappa-B Activator 1Act1Traf3-Interacting Protein 2 |
| Database Links | |
| Cellular Localisation | |
| Alternative Protein Names | E3 Ubiquitin Ligase Traf3ip2 proteinAdapter Protein Ciks proteinConnection To Ikk And Sapk/Jnk proteinE3 Ubiquitin-Protein Ligase Ciks proteinNuclear Factor Nf-Kappa-B Activator 1 proteinAct1 proteinTraf3-Interacting Protein 2 proteinTRAF3IP2 proteinC6orf2 proteinC6orf4 proteinC6orf5 proteinC6orf6 protein |
Information sourced from Uniprot.org