| Function | E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling. Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein. Essential adapter molecule in IL17A-mediated signaling. Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways. |
| Protein Name | E3 Ubiquitin Ligase Traf3ip2Adapter Protein CiksConnection To Ikk And Sapk/JnkE3 Ubiquitin-Protein Ligase CiksNuclear Factor Nf-Kappa-B Activator 1Act1Traf3-Interacting Protein 2 |
| Alternative Protein Names | E3 Ubiquitin Ligase Traf3ip2 proteinAdapter Protein Ciks proteinConnection To Ikk And Sapk/Jnk proteinE3 Ubiquitin-Protein Ligase Ciks proteinNuclear Factor Nf-Kappa-B Activator 1 proteinAct1 proteinTraf3-Interacting Protein 2 proteinTRAF3IP2 proteinC6orf2 proteinC6orf4 proteinC6orf5 proteinC6orf6 protein |
Information sourced from Uniprot.org
