| Function | Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types. In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome. Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines. Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance. Acts also as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. |
| Protein Name | Tnf Receptor-Associated Factor 3Cd40 Receptor-Associated Factor 1Craf1Cd40-Binding ProteinCd40bpLmp1-Associated Protein 1Lap1Ring-Type E3 Ubiquitin Transferase Traf3 |
| Database Links | Reactome: R-HSA-5602571Reactome: R-HSA-5668541Reactome: R-HSA-5676594Reactome: R-HSA-5689896Reactome: R-HSA-9013973Reactome: R-HSA-918233Reactome: R-HSA-936440Reactome: R-HSA-936964Reactome: R-HSA-9692916Reactome: R-HSA-9705671Reactome: R-HSA-9824878Reactome: R-HSA-9828211 |
| Cellular Localisation | CytoplasmEndosomeMitochondrionUndergoes Endocytosis Together With Tlr4 Upon Lps SignalingCo-Localized To Mitochondria With Trim35 |
| Alternative Protein Names | Tnf Receptor-Associated Factor 3 proteinCd40 Receptor-Associated Factor 1 proteinCraf1 proteinCd40-Binding Protein proteinCd40bp proteinLmp1-Associated Protein 1 proteinLap1 proteinRing-Type E3 Ubiquitin Transferase Traf3 proteinTRAF3 proteinCAP-1 proteinCRAF1 proteinTRAFAMN protein |
Information sourced from Uniprot.org
