| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human TRADD-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | TRADD |
| Gene ID: | 8717 |
| Uniprot ID: | TRADD_HUMAN |
| Immunogen Region: | Met61-Leu297 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | (Microbial infection) Glycosylated at Arg-235 by enteropathogenic E.coli protein NleB1, C.rodentium protein NleB and S.typhimurium proteins Ssek1 and Ssek3: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions and assembly of the oligomeric TNFRSF1A/TNFR1 complex, thereby disrupting TNF signaling. |
| Function | Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. |
| Protein Name | Tumor Necrosis Factor Receptor Type 1-Associated Death Domain ProteinTnfr1-Associated Death Domain ProteinTnfrsf1a-Associated Via Death Domain |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5675482Reactome: R-HSA-69416Reactome: R-HSA-75893Reactome: R-HSA-9693928 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonShuttles Between The Cytoplasm And The Nucleus |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Type 1-Associated Death Domain Protein proteinTnfr1-Associated Death Domain Protein proteinTnfrsf1a-Associated Via Death Domain proteinTRADD protein |
Information sourced from Uniprot.org