| Short Description : | Recombinant-Human TPRKB-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications: | SDS-PAGE |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 0.5 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.15M NaCl |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TPRKB |
| Gene ID: | 51002 |
| Uniprot ID: | TPRKB_HUMAN |
| Accession Number: | NP_057142 |
| Immunogen: | Human |
| Immunogen Region: | 1-1756aa |
| Immunogen Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMQLTHQ LDLFPECRVT LLLFKDVKNA GDLRRKAMEG TIDGSLINPT VIVDPFQILV AANKAVHLYK LGKMKTRTLS TEIIFNLSPN NNISEALKKF GISANDTSIL IVYIEEGEKQ INQEYLISQV EGHQVSLKNL PEIMNITEVK KIYKLSSQEE SIGTLLDAII CRMSTKDVL |
| Tissue Specificity | Widely expressed. |
| Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification. |
| Protein Name | Ekc/Keops Complex Subunit TprkbPrpk-Binding ProteinTp53rk-Binding Protein |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | CytoplasmCytosolNucleus |
| Alternative Protein Names | Ekc/Keops Complex Subunit Tprkb proteinPrpk-Binding Protein proteinTp53rk-Binding Protein proteinTPRKB proteinCGI-121 proteinMy019 protein |
Information sourced from Uniprot.org