| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.247ng/mL |
| Detection Limit: | 0.625-40ng/mL |
| Short Description : | This TPM2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | TPM2 |
| Gene ID: | 7169 |
| Uniprot ID: | TPM2_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | Present in primary breast cancer tissue, absent from normal breast tissue. |
| Post Translational Modifications | Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization. |
| Function | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. |
| Protein Name | Tropomyosin Beta Chain Beta-Tropomyosin Tropomyosin-2 |
| Database Links | Reactome: R-HSA-390522 Reactome: R-HSA-445355 |
| Cellular Localisation | Cytoplasm Cytoskeleton Associates With F-Actin Stress Fibers |
| Alternative ELISA Names | Tropomyosin Beta Chain ELISA kit Beta-Tropomyosin ELISA kit Tropomyosin-2 ELISA kit TPM2 ELISA kit TMSB ELISA kit |
| output |
Information sourced from Uniprot.org