Human TOP2A protein (Recombinant) (N-His) (STJP004005)

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STJP004005
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TOP2A-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TOP2A
Gene ID: 7153
Uniprot ID: TOP2A_HUMAN
Immunogen Region: Ile923-Arg1148
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation. (Microbial infection) Deubiquitinated by Epstein-Barr virus BPLF1.leading to stabilized SUMOylated TOP2A trapped in cleavage complexes, which halts the DNA damage response to TOP2A-induced double-strand DNA breaks. SUMOylated.
Function Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. May play a role in regulating the period length of BMAL1 transcriptional oscillation.
Protein Name Dna Topoisomerase 2-Alpha
Dna Topoisomerase Ii - Alpha Isozyme
Database Links Reactome: R-HSA-1362277
Reactome: R-HSA-4615885
Cellular Localisation Cytoplasm
Nucleus
Nucleoplasm
Nucleolus
Alternative Protein Names Dna Topoisomerase 2-Alpha protein
Dna Topoisomerase Ii - Alpha Isozyme protein
TOP2A protein
TOP2 protein

Information sourced from Uniprot.org

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