Human TOLLIP protein (Recombinant) (N-His) (STJP005973)

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STJP005973
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TOLLIP-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TOLLIP
Gene ID: 54472
Uniprot ID: TOLIP_HUMAN
Immunogen Region: Gln28-Asp261
Immunogen: Homo sapiens (Human)
Function Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates. In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P).
Protein Name Toll-Interacting Protein
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-9020702
Cellular Localisation Cytoplasm
Endosome
Early Endosome
Localized To Endo/Exosomal Vesicles
Alternative Protein Names Toll-Interacting Protein protein
TOLLIP protein

Information sourced from Uniprot.org

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