Human TNKS2 protein (Recombinant) (N-His) (STJP006698)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TNKS2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TNKS2 |
| Gene ID | 80351 |
| Uniprot ID | TNKS2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser959-Gly1166 |
Additional Info
| Post Translational Modifications | Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated.this leads to degradation. Deubiquitinated by USP25.leading to stabilization. ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer. |
| Function | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity. |
| Protein Name | Poly Adp-Ribose Polymerase Tankyrase-2Adp-Ribosyltransferase Diphtheria Toxin-Like 6Artd6Poly Adp-Ribose Polymerase 5bProtein Poly-Adp-Ribosyltransferase Tankyrase-2Tnks-2Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2Tankyrase IiTankyrase-2Tank2Tankyrase-Like ProteinTankyrase-Related Protein |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-4641257Reactome: R-HSA-5545619Reactome: R-HSA-5689880Reactome: R-HSA-8948751 |
| Cellular Localisation | CytoplasmGolgi Apparatus MembranePeripheral Membrane ProteinNucleusChromosomeTelomereAssociated With The Golgi And With Juxtanuclear Slc2a4/Glut4-VesiclesAlso Found Around The Pericentriolar Matrix Of Mitotic CentromeresDuring InterphaseA Small Fraction Of Tnks2 Is Found In The NucleusAssociated With Trf1 |
| Alternative Protein Names | Poly Adp-Ribose Polymerase Tankyrase-2 proteinAdp-Ribosyltransferase Diphtheria Toxin-Like 6 proteinArtd6 proteinPoly Adp-Ribose Polymerase 5b proteinProtein Poly-Adp-Ribosyltransferase Tankyrase-2 proteinTnks-2 proteinTrf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2 proteinTankyrase Ii proteinTankyrase-2 proteinTank2 proteinTankyrase-Like Protein proteinTankyrase-Related Protein proteinTNKS2 proteinPARP5B proteinTANK2 proteinTNKL protein |
Information sourced from Uniprot.org