Human TNKS2 protein (Recombinant) (N-His) (STJP006698)

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STJP006698
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TNKS2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TNKS2
Gene ID: 80351
Uniprot ID: TNKS2_HUMAN
Immunogen Region: Ser959-Gly1166
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated.this leads to degradation. Deubiquitinated by USP25.leading to stabilization. ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer.
Function Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity.
Protein Name Poly Adp-Ribose Polymerase Tankyrase-2
Adp-Ribosyltransferase Diphtheria Toxin-Like 6
Artd6
Poly Adp-Ribose Polymerase 5b
Protein Poly-Adp-Ribosyltransferase Tankyrase-2
Tnks-2
Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2
Tankyrase Ii
Tankyrase-2
Tank2
Tankyrase-Like Protein
Tankyrase-Related Protein
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-4641257
Reactome: R-HSA-5545619
Reactome: R-HSA-5689880
Reactome: R-HSA-8948751
Cellular Localisation Cytoplasm
Golgi Apparatus Membrane
Peripheral Membrane Protein
Nucleus
Chromosome
Telomere
Associated With The Golgi And With Juxtanuclear Slc2a4/Glut4-Vesicles
Also Found Around The Pericentriolar Matrix Of Mitotic Centromeres
During Interphase
A Small Fraction Of Tnks2 Is Found In The Nucleus
Associated With Trf1
Alternative Protein Names Poly Adp-Ribose Polymerase Tankyrase-2 protein
Adp-Ribosyltransferase Diphtheria Toxin-Like 6 protein
Artd6 protein
Poly Adp-Ribose Polymerase 5b protein
Protein Poly-Adp-Ribosyltransferase Tankyrase-2 protein
Tnks-2 protein
Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2 protein
Tankyrase Ii protein
Tankyrase-2 protein
Tank2 protein
Tankyrase-Like Protein protein
Tankyrase-Related Protein protein
TNKS2 protein
PARP5B protein
TANK2 protein
TNKL protein

Information sourced from Uniprot.org

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