| Host: |
E.coli |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of 50mM Tris, 150mM NaCl, pH 8.0. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
Please contact us for more information. |
| Immunoreactivity: |
1.Measured by its binding ability in a functional ELISA. Immobilized recombinant human BAFF at 5 Mu g/mL (100 Mu L/well) can bind recombinant human BCMA with a linear range of 3-20 ng/mL.|2.Measured in a cell proliferation assay using anti-IgM stimul |
| Gene Symbol: |
TNFSF13B |
| Gene ID: |
10673 |
| Uniprot ID: |
TN13B_HUMAN |
| Immunogen Region: |
Ala134-Leu285 |
| Immunogen: |
Recombinant Human TNFSF13B/BAFF/CD257 Protein is produced by E. coli expression system. The target protein is expressed with sequence ( Ala134-Leu285) of human TNFSF13B (Accession #NP_006564.1). |
| Immunogen Sequence: |
IVIGPGRGFGKRRHPKKLTP LAYKQFIPNVAEKTLGASGR YEGKISRNSERFKELTPNYN PDIIFKDEENTGADRLMTQR CKDKLNALAISVMNQWPGVK LRVTEGWDEDGHHSEESLHY EGRAVDITTSDRDRSKYGML ARLAVEAGFDWVYYESKAHI HCSVKAENSVAAKSGG |
| Tissue Specificity | Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. |
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. N-glycosylated. |
| Function | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 13bB Lymphocyte StimulatorBlysB-Cell-Activating FactorBaffDendritic Cell-Derived Tnf-Like MoleculeTnf- And Apol-Related Leukocyte Expressed Ligand 1Tall-1Cd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5669034Reactome: R-HSA-5676594 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTumor Necrosis Factor Ligand Superfamily Member 13bSoluble Form: Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 13b proteinB Lymphocyte Stimulator proteinBlys proteinB-Cell-Activating Factor proteinBaff proteinDendritic Cell-Derived Tnf-Like Molecule proteinTnf- And Apol-Related Leukocyte Expressed Ligand 1 proteinTall-1 proteinCd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form proteinTNFSF13B proteinBAFF proteinBLYS proteinTALL1 proteinTNFSF20 proteinZTNF4 proteinUNQ401 proteinPRO738 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
