human TNFSF13B/BAFF/CD257 protein (Recombinant) (N-6His) (STJP001909)

human TNFSF13B/BAFF/CD257 protein (Recombinant) (N-6His) (STJP001909)

SKU:
STJP001909
£106.50 - £443.50
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g
Immunoreactivity: Measured by its binding ability in a functional ELISA.Immobilized Human TNFSF13B at 5 Mu g/mL (100 Mu L/well) can bind Human TNFRSF17 with a linear range of 0.001-2.3 ng/mL.
Gene Symbol: TNFSF13B
Gene ID: 10673
Uniprot ID: TN13B_HUMAN
Immunogen Region: Ala134-Leu285
Immunogen: Recombinant human TNFSF13B/BAFF/CD257 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala134-Leu285) of human TNFSF13B/BAFF/CD257 (Accession #NP_006564.1) fused with a 6×His tag at the N-terminus.
Immunogen Sequence: AVQGPEETVTQDCLQLIADS ETPTIQKGSYTFVPWLLSFK RGSALEEKENKILVKETGYF FIYGQVLYTDKTYAMGHLIQ RKKVHVFGDELSLVTLFRCI QNMPETLPNNSCYSAGIAKL EEGDELQLAIPRENAQISLD GDVTFFGALKLL
Post Translational Modifications The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. N-glycosylated.
Function Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
Protein Name Tumor Necrosis Factor Ligand Superfamily Member 13b
B Lymphocyte Stimulator
Blys
B-Cell-Activating Factor
Baff
Dendritic Cell-Derived Tnf-Like Molecule
Tnf- And Apol-Related Leukocyte Expressed Ligand 1
Tall-1
Cd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form
Database Links Reactome: R-HSA-5668541
Reactome: R-HSA-5669034
Reactome: R-HSA-5676594
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Tumor Necrosis Factor Ligand Superfamily Member 13b
Soluble Form: Secreted
Alternative Protein Names Tumor Necrosis Factor Ligand Superfamily Member 13b protein
B Lymphocyte Stimulator protein
Blys protein
B-Cell-Activating Factor protein
Baff protein
Dendritic Cell-Derived Tnf-Like Molecule protein
Tnf- And Apol-Related Leukocyte Expressed Ligand 1 protein
Tall-1 protein
Cd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form protein
TNFSF13B protein
BAFF protein
BLYS protein
TALL1 protein
TNFSF20 protein
ZTNF4 protein
UNQ401 protein
PRO738 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP001665 Human BAFF/TNFSF13B/CD257 Trimer protein (Recombinant) (N-His-Avi) {Biotin} (STJP001665) HEK293
STJP001729 Cynomolgus BAFF/TNFSF13B/CD257 Trimer protein (Recombinant) (N-His-Avi, N-Flag) {Biotin} (STJP001729) HEK293
STJP002008 Human C1QC protein (Recombinant) (N-6His & N-hFc) (STJP002008) HEK293 cells
STJP001933 Human IL-31 protein (Recombinant) (N-6His) (STJP001933) HEK293 cells
STJP000674 Human BAFF-R (CD268) protein (Recombinant) (STJP000674) HEK293
STJP001900 Human CD70/TNFSF7/CD27 Ligand protein (Recombinant) (N-6His) (STJP001900) HEK293 cells
STJE0001915 Human CD257/TNFSF13B (Tumor necrosis factor ligand superfamily member 13B) Sandwich ELISA Kit (STJE0001915) Human ELISA
!