Human TNFSF12 protein (Recombinant) (N-His) (STJP003278)

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STJP003278
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TNFSF12-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TNFSF12
Gene ID: 407977/8742
Uniprot ID: TNF12_HUMAN
Immunogen Region: Asp65-Gln247
Immunogen: Homo sapiens (Human)
Post Translational Modifications The soluble form derives from the membrane form by proteolytic processing.
Function Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.
Protein Name Tumor Necrosis Factor Ligand Superfamily Member 12
Apo3 Ligand
Tnf-Related Weak Inducer Of Apoptosis
Tweak Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 12 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 12 - Secreted Form
Database Links Reactome: R-HSA-5668541
Reactome: R-HSA-5676594
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Tumor Necrosis Factor Ligand Superfamily Member 12
Secreted Form: Secreted
Isoform Twe-Pril: Cell Membrane
Single-Pass Membrane Protein
Alternative Protein Names Tumor Necrosis Factor Ligand Superfamily Member 12 protein
Apo3 Ligand protein
Tnf-Related Weak Inducer Of Apoptosis protein
Tweak Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 12 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 12 - Secreted Form protein
TNFSF12 protein
APO3L protein
DR3LG protein
UNQ181 protein
PRO207 protein

Information sourced from Uniprot.org

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