| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized recombinant Human CD30/TNFRSF8 at 2 Mu g/mL (100 Mu L/well) can bind recombinant Human CD30L with a linear range of 1.22-15.23 ng/mL. |
| Gene Symbol: | TNFRSF8 |
| Gene ID: | 943 |
| Uniprot ID: | TNR8_HUMAN |
| Immunogen Region: | Phe19-Lys379 |
| Immunogen: | Recombinant Human TNFRSF8/CD30 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe19-Lys379) of human CD30/TNFRSF8 (Accession #NP_001234.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | FPQDRPFEDTCHGNPSHYYD KAVRRCCYRCPMGLFPTQQC PQRPTDCRKQCEPDYYLDEA DRCTACVTCSRDDLVEKTPC AWNSSRVCECRPGMFCSTSA VNSCARCFFHSVCPAGMIVK FPGTAQKNTVCEPASPGVSP ACASPENCKEPSSGTIPQAK PTPVSPATSSASTMPVRGGT RLAQEAASKLTRAPDSPSSV GRPSSDPGLSPTQPCPEGSG DCRKQCEPDYYLDEAGRCT |
| Post Translational Modifications | Phosphorylated on serine and tyrosine residues (Probable). Isoform 2 is constitutively phosphorylated. |
| Function | Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 8Cd30l ReceptorKi-1 AntigenLymphocyte Activation Antigen Cd30Cd Antigen Cd30 |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cytoplasm |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 8 proteinCd30l Receptor proteinKi-1 Antigen proteinLymphocyte Activation Antigen Cd30 proteinCd Antigen Cd30 proteinTNFRSF8 proteinCD30 proteinD1S166E protein |
Information sourced from Uniprot.org