| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human CD40 Ligand at 2 Mu g/mL (100 Mu L/well) can bind Recombinant Human CD40 with a linear range of 224-898 ng/mL. |
| Gene Symbol: |
CD40 |
| Gene ID: |
958 |
| Uniprot ID: |
TNR5_HUMAN |
| Immunogen: |
Recombinant Human TNFRSF5/CD40 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu21-Arg193) of human CD40/TNFRSF5 (Accession #NP_001241.1) fused with a Fc, 6×His tag at the C-terminus. |
| Immunogen Sequence: |
EPPTACREKQYLINSQCCSL CQPGQKLVSDCTEFTETECL PCGESEFLDTWNRETHCHQH KYCDPNLGLRVQQKGTSETD TICTCEEGWHCTSEACESCV LHRSCSPGFGVKQIATGVSD TICEPCPVGFFSNVSSAFEK CHPWTSCETKDLVVQQAGTN KTDVVCGPQDRLR |
| Function | Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 5B-Cell Surface Antigen Cd40Bp50Cd40l ReceptorCdw40Cd Antigen Cd40 |
| Database Links | Reactome: R-HSA-198933 P25942-1Reactome: R-HSA-5668541 P25942-1Reactome: R-HSA-5676594 P25942-1 |
| Cellular Localisation | Isoform I: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform Ii: Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 5 proteinB-Cell Surface Antigen Cd40 proteinBp50 proteinCd40l Receptor proteinCdw40 proteinCd Antigen Cd40 proteinCD40 proteinTNFRSF5 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
