Human TNFRSF21/DR6 protein (Recombinant) (C-hFc&His) (STJP001345)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenActive Recombinant Human TNFRSF21/DR6 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln42-Leu350) of human TNFRSF21/DR6 (Accession #NP_055267.1) fused with a Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human TNFRSF21/DR6-C-hFc&His protein was developed in hek293 cells using the region Gln42-Leu350. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA.Immobilized Human APP at 10 Mu g/mL (100 Mu L/well) can bind Mouse DR6 with a linear range of 0.002-1.8 Mu g/mL. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | TNFRSF21 |
| Gene ID | 27242 |
| Uniprot ID | TNR21_HUMAN |
| Immunogen | Active Recombinant Human TNFRSF21/DR6 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln42-Leu350) of human TNFRSF21/DR6 (Accession #NP_055267.1) fused with a Fc, 6×His tag at the C-terminus. |
| Immunogen Region | Gln42-Leu350 |
| Immunogen Sequence | QPEQKASNLIGTYRHVDRAT GQVLTCDKCPAGTYVSEHCT NTSLRVCSSCPVGTFTRHEN GIEKCHDCSQPCPWPMIEKL PCAALTDRECTCPPGMFQSN ATCAPHTVCPVGWGVRKKGT ETEDVRCKQCARGTFSDVPS SVMKCKAYTDCLSQNLVVIK PGTKETDNVCGTLPSFSSST SPSPGTAIFPRPEHMETHEV PSSTYVPKGMNSTESNSSAS VRPKVLSSIQEGTVPDNTS |
Additional Info
| Post Translational Modifications | Oxidized in response to reactive oxygen species (ROS), leading to endocytosis. |
| Function | Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 21Death Receptor 6Cd Antigen Cd358 |
| Database Links | Reactome: R-HSA-1989781 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndocytosed Following Oxidation In Response To Reactive Oxygen Species (Ros) |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 21 proteinDeath Receptor 6 proteinCd Antigen Cd358 proteinTNFRSF21 proteinDR6 proteinUNQ437 proteinPRO868 protein |
Information sourced from Uniprot.org