| Short Description : | Recombinant-Human TNFRSF18/CD357-C-hFc&His protein was developed in hek293 cells using the region Gln26-Glu161. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA.Immobilized Human TNFSF18 at 10 Mu g/mL (100 Mu L/well) can bind Human TNFRSF18 with a linear range of 0.8-14.5 Mu g/mL. |
| Determination Method: | <1 EU/Mu g |
| Gene Symbol: | TNFRSF18 |
| Gene ID: | 8784 |
| Uniprot ID: | TNR18_HUMAN |
| Immunogen: | Recombinant Human TNFRSF18/CD357 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln26-Glu161) of human GITR/TNFRSF18 (Accession #NP_004186.1.) fused with a Fc, 6×His tag at the C-terminus. |
| Immunogen Region: | Gln26-Glu161 |
| Immunogen Sequence: | QRPTGGPGCGPGRLLLGTGT DARCCRVHTTRCCRDYPGEE CCSEWDCMCVQPEFHCGDPC CTTCRHHPCPPGQGVQSQGK FSFGFQCIDCASGTFSGGHE GHCKPWTDCTQFGFLTVFPG NKTHNAVCVPGSPPAE |
| Function | Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 18Activation-Inducible Tnfr Family ReceptorGlucocorticoid-Induced Tnfr-Related ProteinCd Antigen Cd357 |
| Database Links | Reactome: R-HSA-5669034Reactome: R-HSA-8877330 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 18 proteinActivation-Inducible Tnfr Family Receptor proteinGlucocorticoid-Induced Tnfr-Related Protein proteinCd Antigen Cd357 proteinTNFRSF18 proteinAITR proteinGITR proteinUNQ319 proteinPRO364 protein |
Information sourced from Uniprot.org
