| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human TNFRSF18/CD357-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF18 at 10 Mu g/mL (100 Mu L/well) can bind Human TNFRSF18 with a linear range of 0.8-14.5 Mu g/mL. |
| Gene Symbol: |
TNFRSF18 |
| Gene ID: |
8784 |
| Uniprot ID: |
TNR18_HUMAN |
| Immunogen: |
Recombinant Human TNFRSF18/CD357 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln26-Glu161) of human GITR/TNFRSF18 (Accession #NP_004186.1.) fused with a Fc, 6×His tag at the C-terminus. |
| Function | Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 18Activation-Inducible Tnfr Family ReceptorGlucocorticoid-Induced Tnfr-Related ProteinCd Antigen Cd357 |
| Database Links | Reactome: R-HSA-5669034Reactome: R-HSA-8877330 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 18 proteinActivation-Inducible Tnfr Family Receptor proteinGlucocorticoid-Induced Tnfr-Related Protein proteinCd Antigen Cd357 proteinTNFRSF18 proteinAITR proteinGITR proteinUNQ319 proteinPRO364 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
