Human TNFR2 (CD120b) protein (Recombinant) (STJP000475)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encoding extracellular domain of Human TNF receptor type 2 (TNFR2) including a C-terminal 6His tag was expressed in HEK293 cells. NA
General Information
| Short Description | Recombinant-Human TNFR2 (CD120b)-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | 0.2 Mu m filtered PBS solution, pH7.2. |
| Storage Instruction | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Immunoreactivity | Recombinant Human TNF receptor 2 (CD120b) activity was determined by the ability to inhibit the TNF Alpha mediated cytotoxicity in the L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is |
Target Information
| Gene Symbol | TNFRSF1B |
| Gene ID | 7133 |
| Uniprot ID | TNR1B_HUMAN |
| Immunogen | Optimized DNA sequence encoding extracellular domain of Human TNF receptor type 2 (TNFR2) including a C-terminal 6His tag was expressed in HEK293 cells. NA |
| Immunogen Region | ECD |
Additional Info
| Post Translational Modifications | Phosphorylated.mainly on serine residues and with a very low level on threonine residues. A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing. |
| Function | Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 1bTumor Necrosis Factor Receptor 2Tnf-R2Tumor Necrosis Factor Receptor Type IiTnf-RiiTnfr-IiP75P80 Tnf-Alpha ReceptorCd Antigen Cd120bEtanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2Tbp-2Tbpii |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5669034Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-6798695 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: SecretedTumor Necrosis Factor-Binding Protein 2: Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 1b proteinTumor Necrosis Factor Receptor 2 proteinTnf-R2 proteinTumor Necrosis Factor Receptor Type Ii proteinTnf-Rii proteinTnfr-Ii proteinP75 proteinP80 Tnf-Alpha Receptor proteinCd Antigen Cd120b proteinEtanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2 proteinTbp-2 proteinTbpii proteinTNFRSF1B proteinTNFBR proteinTNFR2 protein |
Information sourced from Uniprot.org