| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human TMPO-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | TMPO |
| Gene ID: | 7112 |
| Uniprot ID: | LAP2B_HUMAN |
| Immunogen Region: | Met1-Leu243 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Mitosis-specific phosphorylation specifically abolishes its binding to lamin B and chromosomes. Citrullinated by PADI4. |
| Function | May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95. Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| Protein Name | Lamina-Associated Polypeptide 2 - Isoforms Beta/GammaThymopoietin - Isoforms Beta/GammaTp Beta/GammaThymopoietin-Related Peptide Isoforms Beta/GammaTprp Isoforms Beta/Gamma Cleaved Into - ThymopoietinTpSplenin - ThymopentinTp5 |
| Database Links | Reactome: R-HSA-2980766 P42167-1Reactome: R-HSA-2995383 P42167-1Reactome: R-HSA-4419969 P42167-1Reactome: R-HSA-8980692Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408Reactome: R-HSA-9013409Reactome: R-HSA-9013423Reactome: R-HSA-9035034 |
| Cellular Localisation | Nucleus Inner MembraneSingle-Pass Type Ii Membrane ProteinTightly Associated With The Nuclear LaminaIsoform Zeta: Cytoplasm |
| Alternative Protein Names | Lamina-Associated Polypeptide 2 - Isoforms Beta/Gamma proteinThymopoietin - Isoforms Beta/Gamma proteinTp Beta/Gamma proteinThymopoietin-Related Peptide Isoforms Beta/Gamma proteinTprp Isoforms Beta/Gamma Cleaved Into - Thymopoietin proteinTp proteinSplenin - Thymopentin proteinTp5 proteinTMPO proteinLAP2 protein |
Information sourced from Uniprot.org