Human TMEFF1 protein (Recombinant) (N-His) (STJP008746)

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STJP008746
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TMEFF1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TMEFF1
Gene ID: 100526694/8577
Uniprot ID: TEFF1_HUMAN
Immunogen Region: Gly86-Glu302
Immunogen: Homo sapiens (Human)
Function Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry. Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent. Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane. Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors. May be a tumor suppressor in brain cancers.
Protein Name Tomoregulin-1
Tr-1
H7365
Transmembrane Protein With Egf-Like And One Follistatin-Like Domain
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Tomoregulin-1 protein
Tr-1 protein
H7365 protein
Transmembrane Protein With Egf-Like And One Follistatin-Like Domain protein
TMEFF1 protein
C9orf2 protein

Information sourced from Uniprot.org

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