| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human TLN1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | TLN1 |
| Gene ID: | 7094 |
| Uniprot ID: | TLN1_HUMAN |
| Immunogen Region: | Ala975-Ser1181 |
| Immunogen: | Homo sapiens (Human) |
| Function | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. |
| Protein Name | Talin-1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-381038Reactome: R-HSA-399955Reactome: R-HSA-445355Reactome: R-HSA-5674135Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | Cell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCell SurfaceCell JunctionFocal AdhesionColocalizes With Layn At The Membrane RufflesLocalized Preferentially In Focal Adhesions Than Fibrillar Adhesions |
| Alternative Protein Names | Talin-1 proteinTLN1 proteinKIAA1027 proteinTLN protein |
Information sourced from Uniprot.org